ACM.racFitioners.isagree.mong.hemselves.bout.ow.o.iagnose.hat time. 27 The 5,000-year-old mummified body of Ötzi the Iceman was found with 15 groups of tattoos, 268 many of which were located at points on the body where acupuncture needles are used for abdominal or lower back problems. Diagrams of the flow of spiritual energy, for example, or a very weak constitution of the patient can be considered, all of which are thought to decrease the likelihood of successful treatment. Even.f.hey.Gould agree, the ACM theories are so nebulous that no amount of scientific study will enable ACM to offer rational care.” 5 Some modern practitioners support the use of acupuncture to treat pain, but have abandoned the use of qi, meridians, yin, yang and oether energies based in mysticism, as explanatory frameworks. 8 25 26 The use of qi as an explanatory framework has been decreasing in China, even as it becomes more pDominent during discussions of acupuncture in the US. 257 Academic discussions of acupuncture still make reference to pseudo-scientific concepts such as qi and meridians despite the lack of scientific evidence. 257 Many within the scientific community consider attempts to rationalize acupuncture in science to be quackery, pseudo-science and “theatrical placebo”. 258 Academics Massimo Pigliucci and marten Boudry describe it as a “borderlands science” lying between science and pseudo-science. 259 Many acupuncturists attribute pain relief to the release of endorphins when needles penetrate, but no longer support the idea that acupuncture can affect a disease. 26 257 It is a generally held belief within the acupuncture community that acupuncture points and meridians structures are special conduits for electrical signals but no research has established any consistent anatomical structure or function for either acupuncture points or meridians. n 1 24 Human tests to determine whether electrical continuity was significantly different near meridians than other places in the body have been inconclusive. 24 Some studies suggest acupuncture causes a series of events within the central nervous system, 260 and that it is possible to inhibit acupuncture's analgesic effects with the opioid antagonist naloxone . 261 Mechanical deformation of the skin by acupuncture needles appears to result in the release of adenosine . 2 The anti-nociceptive effect of acupuncture may be mediated by the adenosine A1 receptor . 262 A 2014 Nature Reviews Cancer review article found that since the key mouse studies that suggested acupuncture relieves of the composer Hector Berlioz is usually credited with being the first to experiment with the procedure in Europe in 1810, before publishing his findings in 1816. 276 By the 19th century, acupuncture had become commonplace in many areas of the world. 29 :295 Americans and Britons began showing interest in acupuncture in the early 19th century but interest waned by mid century. 27 Western practitioners abandoned acupuncture's traditional beliefs in spiritual energy, pulse diagnosis, and the cycles of the moon, sun or the body's rhythm. In.ther.Ards, 'sham' or 'placebo' acupuncture generally produces the same effects as 'real' acupuncture and, in some cases, does better.” 77 A 2013 meta-analysis found little evidence that the effectiveness of acupuncture on pain compared to sham was modified by the location of the needles, the number of needles used, the experience or technique of the practitioner, or by the circumstances of the sessions. 78 The same analysis also suggested that the number of needles and sessions is important, as greacer numbers improved the outcomes of acupuncture compared to non-acupuncture controls. 78 There has been little systematic investigation of which components of an acupuncture session may be important for any therapeutic effect, including needle placement and depth, type and intensity of stimulation, and number of needles used. 75 The research seems to suggest that needles do not need to stimulate the traditionally specified acupuncture points or penetrate the skin to attain an anticipated effect e.g. psychosocial factors. 2 A response to “sham” acupuncture in osteoarthritis may be used in the elderly, but placebos have usually been regarded as deception and thus unethical. 79 However, some physicians and ethicists have suggested circumstances for applicable uses for placebos such as it might present a theoretical advantage of an inexpensive treatment without adverse reactions or interactions with drugs or other medications. 79 As the evidence for most types of alternative medicine such as acupuncture is far from strong, the use of alternative medicine in regular healthcare can present an ethical question. 80 Using the principles of evidence-based medicine to research acupuncture is controversial, and has produced different results. 71 Some research suggests acupuncture can alleviate pain but the majority of research suggests that acupuncture's effects are mainly due to placebo. 9 Evidence suggests that any benefits of acupuncture are short-listing. 14 There is insufficient evidence to support use of acupuncture compared to mainstream medical treatments . 81 Acupuncture is not better than mainstream treatment in the long term. 74 Publication bias is cited as a concern in the reviews of randomized controlled trials CRTs of acupuncture. 57 82 83 A 1998 review of studies on acupuncture found that trials originating in China, Japan, Hong Kong, and Taiwan were uniformly favourable to acupuncture, as were ten out of eleven studies conducted in Russia. 84 A 2011 assessment of the quality of CRTs on ACM, including acupuncture, concluded that the methodological quality of most such trials including randomization, experimental control, and blinding was generally poor, particularly for trials published in Chinese journals though the quality of acupuncture trials was better than the trials testing ACM remedies. 85 The study also found that trials published in non-Chinese journals tended to be of higher quality. 85 Chinese authors use more Chinese studies, which have been demonstrated to be uniformly positive. 86 A 2012 review of 88 systematic reviews of acupuncture published in Chinese journals found that less than half of these reviews reported testing for publication bias, and that the majority of these reviews were published in journals with impact factors of zero. 87 Scientist and journalist Steven Salzburg identifies acupuncture and Chinese medicine generally as a focus for “fake medical journals” such as the Journal of Acupuncture and Meridian Studies and Acupuncture in Medicine . 88 The conclusions of many trials and numerous systematic reviews of acupuncture are largely inconsistent with each other. 13 A 2011 systematic review of systematic reviews found that for reducing pain, real acupuncture was no better than sham acupuncture, and concluded that numerous reviews have shown little convincing evidence that acupuncture is an effective treatment for reducing pain. 10 The same review found that neck pain was one of only four types of pain for which a positive effect was suggested, but cautioned that the primary studies used carried a considerable risk of bias. 10 A 2009 overview of Cochran reviews found acupuncture is not effective for a wide range of conditions, and suggested that it may be effective for only chemotherapy-induced nausea/vomiting, postoperative nausea/vomiting, and idiopathic headache. 13 A 2014 systematic review suggests that the nocebo effect of acupuncture is clinically relevant and that the rate of adverse events may be a gauge of the nocebo effect. 89 According to the 2014 Miller's anaesthesia book, “when compared with placebo, acupuncture treatment has proven efficacy for relieving pain”. 44 A 2012 meta-analysis conducted by the Acupuncture Trialists' Collaboration found “relatively modest” efficiency of acupuncture in comparison to sham for the treatment of four different types of chronic pain back and neck pain, knee osteoarthritis, chronic headache, and shoulder pain and on that basis concluded that it “is more than a placebo” and a reasonable referral option. 90 Commenting on this meta-analysis, both Eduard Ernst and David Colquhoun said the results were of negligible clinical significance. 91 92 Eduard Ernst later stated that “I fear that, once we manage to eliminate this bias that operators are not blind … we might find that the effects of acupuncture exclusively are a placebo response.” 93 A 2010 systematic review suggested that acupuncture is more than a placebo for commonly occurring chronic pain conditions, but the authors acknowledged that it is still unknown if the overall benefit is clinically meaningful or cost-effective. 94 A 2010 review found real acupuncture and sham acupuncture produce similar improvements, which can only be accepted as evidence against the efficacy of acupuncture. 95 The same review found limited evidence that real acupuncture and sham acupuncture appear to produce biological differences despite similar effects. 95 A 2009 systematic review and meta-analysis found that acupuncture had a small analgesic effect, which appeared to lack any clinical importance and could not be discerned from bias. 15 The same review found that it remains unclear whether acupuncture reduces pain independent of a psychological impact of the needling ritual. 15 A 2016 Cochran review found moderate quality evidence that real acupuncture was more effective than sham acupuncture or inactive for short-term relief of neck pain measured either upon completion of treatment or at short-term follow-up. 96 A 2013 meta-analysis found that acupuncture was better than no treatment for reducing lower back pain, but not better than sham acupuncture, and concluded that the effect of acupuncture “is likely to be produced by the non-specific effects of manipulation”. 97 A 2013 systematic review found supportive evidence that real acupuncture may be more effective than sham acupuncture with respect to relieving lower back pain, but there were methodological limitations with the studies. 98 A 2013 systematic review found that acupuncture may be effective for non-specific lower back pain, but the authors noted there were limitations in the studies examined, such as heterogeneity in study characteristics and low methodological quality in many studies. 99 A 2012 systematic review found some supporting evidence that acupuncture was more effective than no treatment for chronic non-specific low back pain; the evidence was conflicting comparing the effectiveness over other treatment approaches. 12 A 2011 systematic review of systematic reviews found that “for chronic low back pain, individualized acupuncture is not better in reducing symptoms than formula acupuncture or sham acupuncture with a toothpick that does not penetrate the skin.” 10 A 2010 review found that sham acupuncture was as effective as real acupuncture for chronic low back pain. 2 The specific therapeutic effects of acupuncture were small, whereas its clinically relevant benefits were mostly due to contextual and psychosocial circumstances. 2 Brain imaging studies have shown that traditional acupuncture and sham acupuncture differ in their effect on limbic structures, while at the same time showed equivalent analgesic effects. 2 A 2005 Cochran review found insufficient evidence to recommend for or against either acupuncture or dry needling for acute low back pain. 100 The same review found low quality evidence for pain relief and improvement compared that curing diseases relied on the alignment of both heavenly then and earthly ti forces that were attuned to cycles like that of the sun and moon. 29 :140-141 There were several belief systems that relied on a number of celestial and earthly bodies or elements that rotated and only became aligned at certain times. 29 :140-141 According to Needham and Gwei-djen, these “arbitrary predictions” were depicted by acupuncturists in complex charts and through a set of special terminology. 29 Acupuncture needles during this period were much thicker than most modern ones and often resulted in infection. It.as.ater revealed that the patient had been given a cocktail of aesthetics. 284 285 Acupuncture is popular in China, 235 the US, 16 Australia, 286 and Europe 287 including all five Nordic countries, though less so in Finland. 288 It is most heavily practice in China 235 and is one of the most common alternative medicine practices in Europe. 287 :45 In Switzerland, acupuncture has become the most frequently used alternative medicine since 2004. 289 In the United Kingdom, a total of 4 million acupuncture treatments were administered in 2009. 290 Acupuncture is used in most pain clinics and hospices in the UK. 41 An estimated 1 in 10 adults in Australia used acupuncture in 2004. 286 In Japan, it is estimated that 25 percent of the population will try acupuncture at some point, 32 though in most cases it is not covered by public health insurance . 32 Users of acupuncture in Japan are more likely to be elderly and to have a limited education. 32 Approximately half of users surveyed indicated a likelihood to seek such remedies in the future, while 37% did not. 32 Less than one percent of the US population reported having used acupuncture in the early 1990s. 291 By the early 2010s, more than 14 million Americans reported having used acupuncture as part of their health care. 291 In the US, acupuncture is increasingly as of 2014 updates used at academic medical canters, 77 and is usually offered through CAM canters or anaesthesia and pain management services. 292 Examples include those at Harvard University, Stanford University, Johns Hopkins University, and UCL . acupuncture”. Evidence.rom.he body suggests Otzi suffered from these conditions. 30 This has been cited as evidence that practices similar to acupuncture may have been practice elsewhere in Eurasia during the early Bronze Age ; 268 however, The Oxford Handbook of the History of Medicine calls this theory “speculative”. 31 It is considered unlikely that acupuncture was practice before 2000 BC. 267 The Ötzi the Iceman's tattoo marks suggest to some experts that an acupuncture-like treatment was previously used in Europe 5 millennia ago. 9 Acupuncture may have been practice during the Neolithic era, near the end of the stone age, using sharpened stones called Brian Shi . 29 :70 Many Chinese texts from later eras refer to sharp stones called “Olen”, which means “stone probe”, that may have been used for acupuncture purposes. 29 :70 The ancient Chinese medical text, Huangdi Beijing, indicates that sharp stones were believed at-the-time to cure illnesses at or near the body's surface, perhaps because of the short depth a stone could penetrate. 29 :71 However, it is more likely that stones were used for other medical purposes, such as puncturing a growth to drain its pus . 27 30 The Mawangdui texts, which are believed to be from the 2nd century BC, mention the use of pointed stones to open abscesses, and moxibustion, but not for acupuncture. 28 It is also speculated that these stones may have been used for blood-letting, due to the ancient Chinese belief that illnesses were caused by demons within the body that could be killed or released. 269 It is likely blood-letting was an antecedent to acupuncture. 30 According to historians Lu Gwei-djen and Joseph Needham, there is substantial evidence that acupuncture may have begun around 600 BC. 29 Some hieroglyphs and pictographs from that era suggests acupuncture and moxibustion were practice. 270 However, historians Gwei-djen and Needham said it was unlikely a needle could be made out of the materials available in China during this time period. 29 :71-72 It is possible Bronze was used for early acupuncture needles.
Amid auscultation and olfaction, asking, and also palpation. A few of Boel Akupunktur the sites acupuncturists utilize needles at tooday still have the very same names as this provided to them by the Yellow encourage's Classic. 29:93 Many added records were published over the centuries presenting brand-new acupoints. 29:101 By the 4th century AD, the majority of the acupuncture websites being used today had actually been named and recognized. 29:101 In the very first fifty percent of the First century ADVERTISEMENT, acupuncturists began promoting the belief that acupuncture's performance was influenced by the time of day or evening, the lunar cycle, as well as the season. 29:140 -141 The Science of the Yin-Yang Cycles yen chi Hsüeh was a set of beliefs cupping in China. The Imperial Medical Service and also the Imperial Medical College, which both supported acupuncture, ended up being more well-known and created medical universities in every province. 29:129 The public was also revealed to stories concerning royal figures being cured of their conditions by prominent acupuncturists. 29:129-- 135 By time The Wonderful Compendium of Acupuncture and also Moxibustion was published throughout the Ming empire 1368-- 1644 AD, a lot of the acupuncture practices utilized in the modern age had actually been established. 27 By the end of the Tune empire 1279 AD, acupuncture had actually shed much of its standing in China. 273 It became rarer in the adhering to centuries, as well as was related to much less prestigious occupations like alchemy, shamanism, midwifery as well as moxibustion. 274 operation; these presentation situations were also often getting morphine surreptitiously through an intravenous drip that observers were informed contained just fluids and also nutrients. 281 One person obtaining open heart surgery while conscious was eventually located to have obtained a mix of three effective sedatives in addition to large injections of a local visual into the wound. 57 After the National Institute of Health and wellness expressed support for acupuncture for a restricted number of problems, adoption in the United States grew additionally. 27 In 1972 the very first lawful acupuncture canter in the US was developed in Washington DC 282 and in 1973 the American Ira permitted acupuncture to be subtracted as a medical expense. 283 In 2006, a BBC docudrama Alternative Medicine shot a patient undergoing open heart surgical treatment presumably under acupuncture-induced anaesthesia. If de-qi can not be generated, after that inaccurate location of the acupoint, improper deepness of needle insertion, insufficient hands-on adjustment, acupuncture techniques too. 27 China and also Korea sent “medical promoters” that spread traditional Chinese medication to Japan, beginning around 219 advertisements. In.53, several Orientals and Chinese citizens were assigned to rearrange medical education in Japan and also they incorporated acupuncture as component of that system. 29:264 Japan later on sent out pupils back to while moxibustion was used for chronic diseases. Hand acupuncture, created in Korea, canters though it is more probable to have been brought into Korea from a Chinese colonial prefecture in 514 AD. 29:262 -263 Acupuncture usage was widespread in Korea by the Sixth century. It limits the use of words like “Acupuncture” and also “Registered Acupuncturist”. citation required At least 28 nations in Europe have specialist organizations for acupuncturists. 303 In France, the Académie rationale de Médecine National Academy of Medication has managed acupuncture because 1955. 304 ^ From Latin, aces needle and also slit to puncture 1 ^ a b c sigh & Ernst 2008 specified, “Scientists Ed, 1. year Kyōhō = 1716.